Circulating NAD+ Metabolism-Derived Genes Unveils Prognostic and Peripheral Immune Infiltration in Amyotrophic Lateral Sclerosis.

Front Cell Dev Biol · 2022 · PMC8831892 · PMID 35155438

Europe PMC DOI

hedged sentences

0.0540

closest p · 1.1× alpha

0.0540

boldest claim

The sentences

a negative trendp = 0.054so close (0.05 < p ≤ 0.1)

Moreover, analysis of correlations identified a significant negative correlation between NPRS and FVC ( Figure 5L , r = −0.33 p = 0.021); NPRS also showed a negative trend with ALSFRS scores, although it was nearly to reach statistical power ( Figure 5M , r = −0.28, p = 0.054).

also in 4,201 other papers

an increasing trendno p-value reported

Regarding changes in NAD+ consuming enzymes, SIRTs and the biosynthetic catalase of NADP+ (NNT and NADK) showed an increasing trend in blood, whereas PARPs were inconsistently differentially expressed in ALS.

also in 63,971 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.