The global, regional and national burden of peptic ulcer disease from 1990 to 2019: a population-based study.

However, the global age-standardized incidence rate of PUD showed a decreasing trend, at 63.84 (95% UI 54.09 to 75.54) per 100,000 population in 1990 and 44.26 (95% UI 37.32 to 51.87) per 100,000 population in 2019 (Additional file 1 : Table S2).

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pylori infection rate showed a trend of initially increasing and then decreasing with age [ 41 ].

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They account for approximately 5% to 10% of all prescription drugs each year and have shown an increasing trend [ 26 ].

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