nominally significantp = 0.02
Given that there were strong positive correlations between the number of mutations of SBS1 and age at cancer diagnosis in breast cancer (Spearman’s ρ = 0.18, p = 2.50 × 10 −6 ), in colorectal cancer (Spearman’s ρ = 0.24, p = 2.85 × 10 −5 ), and in glioblastoma (Spearman’s ρ = 0.23, p = 1.11 × 10 −4 ); a nominally significant correlation between SBS1 and age in prostate cancer (Spearman’s ρ = 0.12, p = 0.02); and a significant correlation between SBS40 and age in endometrial cancer (Spearman’s ρ = 0.18, p = 9.67 × 10 −4 ), we further evaluated the associations of somatic mutations and PRS without adjusting for age at cancer diagnosis.