Comparison of dosimetric impact of intra-fractional setup discrepancy between multiple- and single-isocenter approaches in linac-based stereotactic radiotherapy of multiple brain metastases.

This difference between SI and MI plans grew with increasing magnitude of shift (Figures 4a‐f ); however, these differences were relatively small and did not reach statistical significance for the brainstem, right optic nerve, and both sides of eyes (Table 4 ).

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