Prognostic Impact of Total Lesion Glycolysis (TLG) from Preoperative ¹⁸F-FDG PET/CT in Stage II/III Colorectal Adenocarcinoma: Extending the Value of PET/CT for Resectable Disease.

In a planned interim report of the FOxTROT phase III trial presented at ASCO 2020, investigating the efficacy and safety of neoadjuvant chemotherapy in 1053 T3-4, N0-2 colon cancer patients, relapse or persistent disease after two years showed a trend toward improvement at 15.6% for neoadjuvant chemotherapy vs. 19.5% for adjuvant chemotherapy ( p = 0.007) [ 43 ].

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According to our data, the majority of the tested PET parameters with different thresholds including SUVmax, MTV2.5, MTV3, TLG2.5, TLG3, and TLG30% discriminated DFS with statistical significance and with marginal significance for MTV30% and TLG40%.

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The differences in DFS rates between cut-off levels were statistically significant in SUVmax, MTV2.5, MTV3, TLG2.5, TLG3, and TLG30%, and at least marginally significant in rest of the PET parameters ( Table 2 ).

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