Dual Inhibition of Myc Transcription and PI3K Activity Effectively Targets Colorectal Cancer Stem Cells.

CD44v6-Positive CR-CSphCs Are Refractory toward BRAF Inhibition While treatment with an inhibitor of BRAF (vemurafenib) reduced the clonogenic activity and delayed in vitro growth of BRAF -mutant CR-CSphCs, the clonogenicity of RAS/BRAF -wt (wt) and KRAS -mutant cells showed a trend towards an increase, without altering the proliferation rate ( Figure 1 A,B and Table 1 ).

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