Modulation of DNA Damage Response by SAM and HD Domain Containing Deoxynucleoside Triphosphate Triphosphohydrolase (SAMHD1) Determines Prognosis and Treatment Efficacy in Different Solid Tumor Types.

Cancers (Basel) · 2022 · PMC8833711 · PMID 35158911

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Interestingly, SAMHD1 KO cells showed a trend to increased expression of both DNA damage and apoptotic markers compared to wild type cells when treated with platinum derivatives ( Figure 4 C,D and Supplementary Figures S6 and S8 ).

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