Multidimensional Functional Profiling of Human Neuropathogenic <i>FOXG1</i> Alleles in Primary Cultures of Murine Pallial Precursors.

By this approach, we found that, compared to Plap -expressing controls, FOXG1 G224S and FOXG1 W308X increased the prevalence of active neurons, by 69.6 ± 2.9% ( p < 0.001, n = 3,3) and 36.4 ± 5.9% ( p < 0.013, n = 3,3), respectively (the corresponding increase displayed by FOXG1 WT samples did not reach statistical significance).

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