Insights into the Steps of Breast Cancer-Brain Metastases Development: Tumor Cell Interactions with the Blood-Brain Barrier.

Int J Mol Sci · 2022 · PMC8836543 · PMID 35163822

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

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boldest claim

The sentences

almost significantlyp = 6.788 × 10 −12actually significant

Here, MDA-MB-231-BR CM significantly upregulated CXCL1 ( p = 0.0001) and almost significantly downregulated the TXNIP gene level ( p = 6.788 × 10 −12 ) in hBMECs in comparison to MDA-MB-231 CM.

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a clear trendno p-value reported

Despite this limitation in the experimental setting, we observed a clear trend regarding the metastatic potential among the three cell lines.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.