Brain Volume Loss Can Occur at the Rate of Normal Aging in Patients with Multiple Sclerosis Who Are Free from Disease Activity.

BVL was less pronounced in the MS patients with NEDA-3, as compared to those with EDA (original unadjusted groups were used for statistical analyses, demographical data are displayed in Table 1 ), as demonstrated by the 72% difference in mean (± SD) annualized whole brain volume percentage change (−0.25 ± 0.47 versus −0.43 ± 0.63, respectively), although this result did not reach statistical significance (one-tailed p = 0.1371).

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