For MDA-MB-231, KM76 CM-metformin, W1951 CM-metformin and TRI CM-metformin, the cell proliferation was significantly different from control CM, whereas MDA-MB-436 showed a trend versus inhibitory effects of metformin pretreatment that did not reach statistically significance (Fig. 3 A).
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Effects of metformin on human bone-derived mesenchymal stromal cell-breast cancer cell line interactions.
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