Prednisolone reduces the interferon response to AAV in cynomolgus macaques and may increase liver gene expression.

Mol Ther Methods Clin Dev · 2022 · PMC8841522 · PMID 35211641

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28 At the earliest time point at which liver biopsies were performed (day 28), IS animals showed a trend of higher levels of vector DNA and hOTCco mRNA in hepatic tissue when compared with non-IS animals, although the differences were not statistically different.

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