Vascularized pulp regeneration via injecting simvastatin functionalized GelMA cryogel microspheres loaded with stem cells from human exfoliated deciduous teeth.

Differences between groups of ∗ p ​< ​0.05 were considered statistically significant, ∗∗ p ​< ​0.01 and ∗∗∗ p ​< ​0.001 were considered highly significant. 3 Results 3.1 Effect of SIM on SHEDs biological properties To determine whether SIM exerted pro-odontogenic differentiation on SHEDs, we first screened the suitable dose range with no inhibitory effect on SHEDs proliferation and then selected optimized dose of SIM for SHEDs odontogenesis.

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Hence, a strong trend is to develop a growth factor free system with stem cell fate regulating property for pulp regeneration.

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