We considered excluding smokers to obtain a more refined subset of HPV-driven disease; however, we did not want to omit the portion of concomitant smokers and HPV-positive patients who represent an important trend toward worse outcomes.
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Comparison of the Seventh and Eighth Edition of American Joint Committee on Cancer (AJCC) Staging for Selected and Nonselected Oropharyngeal Squamous Cell Carcinomas.
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