Systems analysis of immune responses to attenuated P. falciparum malaria sporozoite vaccination reveals excessive inflammatory signatures correlating with impaired immunity.

PLoS Pathog · 2022 · PMC8843222 · PMID 35108339

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showed a trendp = 0.06so close (0.05 < p ≤ 0.1)

Consistent with the RNAseq data, NP subjects showed a trend towards increased proportions of circulating monocytes shortly after the first immunization, specifically non-classical monocytes (CD14+-CD16+) ( Fig 5A , p = 0.06).

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