Multiple Regulatory Mechanisms Control the Production of CmrRST, an Atypical Signal Transduction System in Clostridioides difficile.

In contrast, when probing immediately downstream of the cmr switch (TSS2/TSS3), cmrR overexpression resulted in 11-fold higher transcript abundance in recV cmr -OFF relative to the vector control, though the difference did not reach statistical significance ( Fig. 5D ).

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