The protein kinase Ire1 has a Hac1-independent essential role in iron uptake and virulence of Candida albicans.

Importantly, expression of the pre-spliced HAC1* also largely restored virulence of the ire1 Δ mutants; the prolonged survival of mice infected with these strains compared to mice infected with the wild type did not reach statistical significance ( Fig 11A , left), and kidney fungal burdens in the two groups of mice were also similar ( Fig 11B ).

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