When samples were stratified by 22q13.33 insertion genotype, prenatal vitamin use during the first month of pregnancy showed a nominally significant protective effect among individuals with the insertion, although we acknowledge that the sample size is small (within samples homozygous for the insertion: in samples from mothers who took prenatal vitamin during the first month of pregnancy, Mann-Whitney-Wilcoxon, p value = 0.046, ASD n = 3, TD n = 4, effect size = −2.09; Additional File 3 : Fig.
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Placental methylome reveals a 22q13.33 brain regulatory gene locus associated with autism.
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