nearly significantp = 0·062
The median change in ace index from baseline in the acupuncture group was significantly better than that in the sham group (difference: 38·0, 95%CI: 3·9–66·7, p = 0·032) and the chao1 index was nearly significant (difference: 30·3, 95%CI: −2·7–61·4, p = 0·062), suggesting a better effect of acupuncture on the enrichment of intestinal microorganisms in patients with CD (Supplementary Tables S2, S3).