Exposure to GABA<sub>A</sub> Receptor Antagonist Picrotoxin in Pregnant Mice Causes Autism-Like Behaviors and Aberrant Gene Expression in Offspring.

Front Psychiatry · 2022 · PMC8850354 · PMID 35185658

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showed a trendp = 0.080so close (0.05 < p ≤ 0.1)

In the righting reflex test, the two-way repeated-measures ANOVA showed a trend toward an effect of picrotoxin treatment [ F (1, 42) = 3.216, p = 0.080], no picrotoxin treatment × day of testing interaction [ F (2, 84) = 1.415, p = 0.249; n = 18 control mice, n = 26 picrotoxin-exposed mice; Figure 2B ], and a significant effect of day of testing [ F (1.424, 59.80) = 39.04, p < 0.0001].

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