HLA-C*04:01 Affects HLA Class I Heterozygosity and Predicted Affinity to SARS-CoV-2 Peptides, and in Combination With Age and Sex of Armenian Patients Contributes to COVID-19 Severity.

Front Immunol · 2022 · PMC8850920 · PMID 35185875

Europe PMC DOI

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closest p

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boldest claim

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showed a trendno p-value reported

After applying Bonferroni’s correction, only the association of the HLA-C*04:01 allele remained significant (P bonf <0.021), while HLA-B*51:01 showed a trend for an association.

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marginal significanceno p-value reported

Thus, the first genome-wide association study (GWAS) reports a trend for HLA-C*04:01 association to the disease severity in the Italian population with a marginal significance, and a significantly lower number of HLA class I bound SARS‐CoV‐2 peptides in the most severe group of the Italian and Spanish patients ( 35 ).

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