<i>Leishmania</i> Exosomes/Extracellular Vesicles Containing GP63 Are Essential for Enhance Cutaneous Leishmaniasis Development Upon Co-Inoculation of <i>Leishmania amazonensis</i> and Its Exosomes.

Again, this GP63 fine-tune existence is supported by our finding that the response on cells stimulated with LeishEXO GP63 Low also showed a trend of increased gene expression of inflammatory cytokines, indicating that low levels of GP63 would lead to disruption of this fine-tune and to permissiveness of an inflammatory response by macrophages caused by LeishEXO per se.

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