Cerebrospinal fluid metallomics in cerebral amyloid angiopathy: an exploratory analysis.

Patients with CAA also had significantly higher CSF iron levels than the AD group (median 23.42 μg/L, vs 15.48 μg/L, p = 0.0006); the difference in medians between the CAA and CS group was of a similar magnitude (median 23.42 μg/L vs 17.71 μg/L), but did not reach statistical significance ( p = 0.09).

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When considering all groups together, there was a significant correlation between CSF Aβ-42 and CSF ferritin (Spearman’s ρ − 0.5057, p = 0.0009); there was a modest correlation between CSF ferritin and Aβ-40 (Spearman’s ρ − 0.3068, p = 0.054), although this did not quite reach statistical significance by our definition.

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