Melanoma-derived extracellular vesicles mediate lymphatic remodelling and impair tumour immunity in draining lymph nodes.

However, many of these changes could also be observed in mLECs and even cLECs (Figure 4D ), although they did not reach statistical significance on those LEC subsets.

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Interestingly, gene ontology analysis of these genes showed a highly significant upregulation of genes associated with the term ‘extracellular exosome,’ indicating that injected EVs might have transferred mRNAs to recipient LECs (Figure 4E ).

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Interestingly, while the rate of living ova‐specific CD8 + T cells was not affected by Rab27a deletion in the primary tumour (Figure 5G ), we noted a slight trend towards reduced apoptosis of these cells, whereas CD8 + T cells specific for the endogenous tumour antigens Pmel and Dct (Tyrp2), which are both present in B16F10‐derived EVs (Table S1 ), showed a significant apoptosis reduction in LNs draining Rab27a ko tumours (Figure 5H‐5I ).

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