Sex hormones, adiposity, and metabolic traits in men and women: a Mendelian randomisation study.

Eur J Endocrinol · 2022 · PMC8859921 · PMID 35049520

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borderline significantno p-value reported

In contrast, only a borderline significant association between elevated BioT and higher BMI persisted in MR analyses using the cluster-filtered genetic instrument, modelling the SHBG-independent effects of testosterone.

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nominally significantno p-value reported

These yielded directionally consistent IVW estimates, which were at least nominally significant in the unfiltered analyses for all the main, primary associations (Supplementary Table 5).

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