Association Between Intensity of Low-Density Lipoprotein Cholesterol Reduction With Statin-Based Therapies and Secondary Stroke Prevention: A Meta-analysis of Randomized Clinical Trials.

4 A subsequent meta-analysis of randomized clinical trials showed that statins were associated with a reduction in the risk of ischemic strokes and cardiovascular events, but the reduction of recurrent stroke did not reach statistical significance. 5 In addition to their LDL-C–lowering effects, statins may exhibit cardiovascular protection via their pleiotropic effects. 6 , 7 The antithrombotic effect of statins may provide additional reduction in ischemic events but may increase the risk of intracranial hemorrhage in patients with ischemic

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