TLC599 in patients with osteoarthritis of the knee: a phase IIa, randomized, placebo-controlled, dose-finding study.

Arthritis Res Ther · 2022 · PMC8862584 · PMID 35189943

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did not reach statistical significanceno p-value reported

Improvements in WOMAC-Pain with TLC599 18 mg did not reach statistical significance compared with placebo for any time interval.

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an increasing trendno p-value reported

In particular, there is an increasing trend in opioid prescription to treat OA pain, with poor patient satisfaction, and increased morbidity and mortality [ 8 ].

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