Vaccine-Induced, High-Magnitude HIV Env-Specific Antibodies with Fc-Mediated Effector Functions Are Insufficient to Protect Infant Rhesus Macaques against Oral SHIV Infection.

A more detailed assessment of Fc-mediated effector functions of Env-specific plasma IgG revealed that vaccine virus-specific ADCC activity was associated with fewer challenges required for infection ( r = −0.761 and unadjusted P = 0.0054), but this inverse correlation did not reach statistical significance after adjustment for multiple-parameter analysis (adjusted P = 0.0984) ( Table 2 ).

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