While 4-MU treatment showed a trend of memory enhancement in all time points of the treatment, significantly enhancement in 3-hour memory retention was found after 2 months of treatment compared to the washout group, and in 24-hour memory retention after 6 months of the treatment as compared to the control and washout group ( Fig. 4 B).
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Oral treatment of 4-methylumbelliferone reduced perineuronal nets and improved recognition memory in mice.
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