The crystal structure of the varicella-zoster Orf24-Orf27 nuclear egress complex spotlights multiple determinants of herpesvirus subfamily specificity.

In each subfamily, a quite significant number of residues (30–40 % of hook residues) can be observed that are strictly conserved within subfamilies including all human herpesviruses ( Figs. 9 E and S10 A ).

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