The Effects of Safinamide Adjunct Therapy on Depression and Apathy in Patients With Parkinson's Disease: <i>Post-hoc</i> Analysis of a Japanese Phase 2/3 Study.

Front Neurol · 2021 · PMC8869178 · PMID 35222225

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did not reach statistical significanceno p-value reported

One of the possible reason for why PDQ-39 emotional well-being did not reach statistical significance might be because of small number of subjects and high variability of scores at baseline in the Japanese study compared to the global phase 3 study ( 35 ).

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