approached significancep = 0.081
We assessed cytosolic PFKFB3 as a proxy marker of enzyme activation and, although no statistically significant changes were observed between treatment groups, DMF decreased cytosolic PFKFB3 in microglia from female mice by 40% which approached significance ( p = 0.081), while no difference in total PFKFB3 was observed ( Figure 3 F).