Prevention of L-Dopa-Induced Dyskinesias by MPEP Blockade of Metabotropic Glutamate Receptor 5 Is Associated with Reduced Inflammation in the Brain of Parkinsonian Monkeys.

In the caudate nucleus at the pre-commissural level significant changes were observed (F (3,14) = 5.898, p = 0.0081), with significant and similar increases in the L-Dopa-treated groups of monkeys (+84%) and in L-Dopa + MPEP (+86%) compared to intact animals, whereas it did not reach statistical significance in the saline-treated MPTP monkeys ( Figure 3 a).

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