The result was a 40% reduction in AHI in the high-dose combination group (fluoxetine 10 mg daily and ondansetron 24 mg daily; p < 0.03) compared to baseline, which was predominantly attributed to fluoxetine use as the ondansetron monotherapy group showed a trend toward increased AHI post-treatment that was not statistically significant in REM and supine sleep.
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Overview of the Role of Pharmacological Management of Obstructive Sleep Apnea.
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