Even considering the large variability observed in the MTT assay measurements ( Figure 7 A), upon testing the toxicities of these distinct G51D oligomers, we identified a clear trend between an increased α-helical content and increased cellular dysfunction ( Figure 7 C).
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The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity.
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