Moreover, the median mtDNA copy number was more than doubled for myopathy-derived fibroblasts, though this only reached borderline significance when compared to healthy-tissue-derived fibroblasts ( p = 0.060; Figure 6 G).
Though the differences were not significant in the small sample size of four myopathy-tissue- and five healthy-tissue-derived skin fibroblasts, the CpT at position 15803 in the CYTB gene showed a borderline significant increase in methylation in myopathy-tissue-derived skin fibroblasts ( p = 0.064; Figure 4 A).