Antirheumatic therapy is associated with reduced complement activation in rheumatoid arthritis.

Changes in LDL-C and triglyceride did not reach statistical significance level (median difference = 0.10 [95% CI = -0.05 to 0.25], p = 0.20 and median difference = -0.02 [95% CI = -0.13 to 0.09], p = 0.72, respectively) Discussion In this study, complement activation as detected by plasma TCC was increased in the majority of patients with active RA, and the complement activation reduced rapidly and sustainably after initiation of antirheumatic treatment.

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