Presence of autoantibodies in serum does not impact the occurrence of immune checkpoint inhibitor-induced hepatitis in a prospective cohort of cancer patients.

J Cancer Res Clin Oncol · 2022 · PMC8881258 · PMID 34874490

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highly significantno p-value reported

However, we found a highly significant difference in the development of multiple irAEs: 9/11 patients in the ICI-induced hepatitis group (81.8%) developed additional irAEs, compared with 15/73 controls with multiple irAEs (20.5%; p = 0.0001).

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nominally significantno p-value reported

We found two nominally significant associations between the occurrence of ICI-induced hepatitis and HLA alleles associated with autoimmune liver diseases among NSCLC patients.

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