As meta-analysis showed a trend towards reduction of non-fatal MI with BA (OR 0.57; p=0.05) and significantly lower rates of new-onset or worsening of DM with BA (OR 0.68; p=0.02), which is an independent CV risk factor, there are indications that BA possibly holds the potential to improve clinical outcomes in selected patients at high CV risk.
26–30 The majority of those focused on BAs capacities in lipid-lowering with comparable results to the current analysis: Allocation to BA as compared with placebo led to highly significant reductions in major atherogenic lipid fractions of LDL-C, non-HDL-C and apoB. 26–29 In contrast, primary interest of the current meta-analysis was to assess evidence on BAs efficacy in improving relevant clinical outcomes, which is the fundamental objective of pharmacological lipid-lowering.