Serum Levels of IL-1 RA Increase with Obesity and Type 2 Diabetes in Relation to Adipose Tissue Dysfunction and are Reduced After Bariatric Surgery in Parallel to Adiposity.

IL-1α and IL-1β levels were below the detection threshold in most of the samples (data not shown). A highly significant correlation ( P <0.001 for all) was found between serum IL-1RA and BMI (r=0.51), BF% (r=0.42), waist circumference (r=0.50), insulin levels (r=0.31), HOMA (r=0.30), QUICKI (r=−0.37), HDL-cholesterol levels (r=−0.27) and uric acid (r=0.33).

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The mRNA expression of TNF and CCL2 showed around a three-fold increase in both groups of patients with obesity, but they did not reach statistical significance likely due to data variability.

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