Diosmetin Protects against Cardiac Hypertrophy via p62/Keap1/Nrf2 Signaling Pathway.

Compared to the only PE-treated group, the induction of ANP, BNP, and β -myosin heavy chain ( β -MHC) transcription by PE for 24 h was clearly suppressed in the presence of diosmetin in a dose-dependent manner ranging between 10 and 50 μ M, whereas the treatment with PE for 12 h in the presence of diosmetin did not reach statistical significance (Figures 2(c) and 2(e) ).

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