The Glycolytic Gatekeeper PDK1 defines different metabolic states between genetically distinct subtypes of human acute myeloid leukemia.

Nat Commun · 2022 · PMC8888573 · PMID 35232995

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a clear trendno p-value reported

While heterogeneity in responses was noted, a clear trend towards greater sensitivity towards DAP was observed in FLT3-wt (mostly PDK1 High ) AMLs (Fig. 5c, e, f ).

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