A Critical Function for the Transcription Factors GLI1 and GLI2 in the Proliferation and Survival of Human Mast Cells.

By 2-3 weeks, when mast cells represent 20-30% of the cell culture, gated Ptch1 +/- BMMC showed, on average, a significant 3-fold reduction in CTV fluorescence intensity (due to dye dilution as cells proliferate) compared to gated Wt BMMC, while by 6 weeks, when mast cells represent >95% of the culture, the reduction in CTV fluorescence intensity in Ptch1 +/- cells was no more than 1.5 over Wt cells and did not reach statistical significance ( Figure 2D ).

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