Genome-Wide Methylation Profiling in the Thalamus of Scrapie Sheep.

We obtained a significant negative correlation between PrP Sc deposits and the percentage of methylated CHG sites ( r = −0.972, p = 0.028) and a negative trend correlation with the percentages of mC sites ( r = −0.942, p = 0.057) and mCHH sites ( r = −0.936, p = 0.064) ( Figure 2A ).

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Although KEGG pathway analysis detected no significant pathways enriched, in hypomethylated DMPs, some pathways displayed a trend toward significance after multiple corrections including terms like apoptosis, lysosomes, protein processing in the endoplasmic reticulum, or AD ( Supplementary Table S12 ).

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