Circulating chemerin levels in metabolic-associated fatty liver disease: a systematic review and meta-analysis.

Nevertheless, highly significant heterogeneity was still observed among these studies [Q = 35.56, degree of freedom (df) = 3, I 2 = 91.6%, P < 0.001; Q = 15.57, degree of freedom (df) = 4, I 2 = 74.3%, P = 0.004].

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There was a significant trend of high chemerin protein levels in Asian subgroups of MAFLD patients (SMD: 1.73; 95% CI: 0.35, 3.10; P = 0.014; Table 2 ), whereas chemerin levels in the others did not differ from the control group in the regional subgroup analysis (SMD: 0.50; 95% CI: -0.61, 1.60; P = 0.378; Table 2 ).

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