Flagellum and toxin phase variation impacts intestinal colonization and disease development in a mouse model of <i>Clostridioides difficile</i> infection.

On d 2, when the differences in weight loss between groups are greatest, the toxin titers in feces collected from flg -Δ3 ON-infected mice were significantly higher than from mice infected with wildtype ( p = 0.0041); toxin titers were also higher than in feces from flg -Δ3 OFF-infected mice, though the differences did not reach statistical significance ( Figure 4e ).

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