Nonopioid drug combinations for cancer pain: a systematic review.

Pain Rep · 2022 · PMC8893303 · PMID 35261931

Europe PMC DOI

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failed to reach statistical significanceno p-value reported

In the first 3 of these trials, trends favouring combination efficacy failed to reach statistical significance.

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a nonsignificant trendno p-value reported

There was a nonsignificant trend toward reduced pain severity and fewer neuropathic pain symptoms in the intervention group after 18 months; however, this group also reported lower quality of life at trial completion.

also in 5,406 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.