<i>Fusobacterium nucleatum</i> is associated with inflammation and poor survival in early-stage HPV-negative tongue cancer.

Consistent with the observation from the in-house tumor samples, the TCGA tongue cancer patients with Fusobacterium -high status showed a trend of poor overall survival (hazard ratio = 1.67, log-rank P -value = 0.14) (Figure 5B ).

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We extended the analysis to the HPV-negative TCGA oral tongue tumor patients and observed a marginally significant difference in the survival, consistent with the in-house tongue cancer samples.

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