Further, these analyses showed a trend towards increased TMA recurrence in patients with complement pathogenic variants; this was particularly notable in patients with CFH and MCP variants (18.2% and 15.0% of patients with these respective variants suffered a TMA recurrence), consistent with previous reports [ 15 , 19–21 ].
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Eculizumab discontinuation in atypical haemolytic uraemic syndrome: TMA recurrence risk and renal outcomes.
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The data also highlighted an increasing trend towards TMA recurrence in patients with a family history of aHUS.