Differences in subcortical brain volumes among patients with schizophrenia and bipolar disorder and healthy controls.

We found nominally significant subcortical volumetric differences in the bilateral thalami (left Cohen d = −0.29, p = 5.83 × 10 −3 ; right d = −0.24, p = 0.025), bilateral hippocampi (left d = −0.36, p = 8.85 × 10 −4 ; right d = −0.41, p = 1.15 × 10 −4 ), bilateral amygdalae (left d = −0.31, p = 4.02 × 10 −3 ; right d = −0.17, p = 0.014) and right nucleus accumbens ( d = −0.21, p = 0.048) between the patients with schizophrenia and controls ( Figure 2A and Figure 3 ).

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We found a significant positive correlation between age at onset and the volume in the left amygdala ( r = 0.22, p = 5.78 × 10 −3 ) and a marginally significant negative correlation between CPZ-eq and left amygdalar volumes ( r = −0.18, p = 0.025) in patients with schizophrenia.

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